Depression and obesity - DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results For DOV 21,947 Part 2

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Eight Phase I study savour presently be completed with DOV 21,947. The double-blind, Phase II study programmed in support of beginning latter this year will compare capable of 100 mg per hours of daylight of DOV 21,947 versus placebo in about 200 patients with core depressive turmoil over and done with a six-week treatment period. The Company expect the grades from this Phase II study will be at your disposal in the fourth quarter of 2008.

DOV 21,947 is a TRIP that inhibit the reuptake of the neurotransmitters serotonin, norepinephrine and dopamine. A two-week carry-on with a 100 mg each day dose of DOV 216,303, the parent merged of DOV 21,947, produced a statistically celebrated reduction in Hamilton Depression Rating Scales in a Phase II clinical trial in patients with major depressive disorder. In animal model importantly predictive of antidepressant action, DOV 21,947 was more potent than Tofranil(R), a serotonin and norepinephrine reuptake inhibitor and the selective serotonin reuptake inhibitors Prozac(R) and Celexa(R). Because of its potential to inhibit the reuptake of the three neurotransmitters consummate familiarly allied to wilt, DOV 21,947 may be more successful and have a more speedy start than other antidepressants which inhibit the reuptake of one or two of these neurotransmitters. This ultramodern league of property in a single-handed molecule could commence a breakthrough in the treatment of depression. In addition, at dose resembling those functional in models predictive of antidepressant action, DOV 21,947 produced a significant luggage passing away in two animal models of diet-induced obesity. Such models of diet-induced obesity be often nearly new to project the utility of drugs to gather round weight loss in obese individuals.

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