Friday, November 14, 2008

Antidepressant Warnings Appear To Be Associated With Decreased Prescription Rates Among Tennessee Children




Antidepressant medication be repetitively once owned to extravagance devaluation among nearest and dearest and teens, but surrounded by 2003 transcript emerge support the pen of an increased chance of suicidal thinking and behavior among babyish patients taking these drugs, according to surroundings gossip in the article. "In December 2003, the Committee on Safety of Medicines [the U.K. linctus regulatory agency] declared the risk-benefit profile of all selective serotonin reuptake inhibitor (SSRI) antidepressants (as resourcefully in place of venlafaxine hydrochloride and mirtazapine), near the imperviousness of fluoxetine, to be unfavorable in favour of the awareness of highest depressive disruptiveness in children and adolescents," the author be in submit yourself to. "Shortly thereafter in 2004, the Food and Drug Administration convene a Psychopharmacology Advisory Committee rendezvous in February, issue a population robustness advisory in March, and in October sought after black sachet deterrent sign for all antidepressants (including fluoxetine) highlighting the promise augmentation in suicidal thinking and behavior in children and adolescents. The warning recommended more concerted medical monitor to mitigate these risk but apply not proffer prevaricate the pediatric misuse of antidepressants." Benji T. Kurian, M.D., M.P.H., and colleagues at Vanderbilt University School of Medicine, Nashville, Tenn., consider monthly antidepressant prescription data among patients age 2 to 17 years thick with the TennCare expanded Medicare program. "The den integrated the 45 months from Jan. 1, 2002, through Sept. 30, 2005, 12 months subsequent the FDA black box warning," the authors write. "The study months be divided into two period. The juncture back the regulatory warning included the 24 months from Jan. 1, 2002, through Dec. 31, 2003, and that after the regulatory warnings included the 21 months from Jan. 1, 2004, through Sept. 30, 2005." An intermediate of 405,000 children and teens qualified for the study respectively month.



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The decrease was furthermost pronounced for SSRIs (except for fluoxetine) and another field of antidepressant associated to suicidal belief and behaviors, selective norepinephrine reuptake inhibitors. New user of fluoxetine, the newly antidepressant accepted by the FDA for the treatment of depression in children and adolescents, increased by 60 percent. "However, there was no rally of an increase in discontinuations of psychotherapy with antidepressant or other psychotropic drugs, which suggest that the former effect of the warnings was to alter the finding to treat a a moment ago present forbearing," the authors write.



Previous study relevant shown that the use of antidepressants among TennCare patients be resembling to that of children and adolescents in the thorough United States, suggesting that a similar decrease may have occur in other populations. Because there is in consequence considerably suspiciously regarding the pediatric use of antidepressants, the implication of these change are amorphous, the authors document. "Thus, while it is in a little evident that regulatory intervention can alter pattern of try-out, whether this is jubilant is tentative," they conclude. "There is an imperative have need of for finer data on the efficacy and sanctuary of antidepressants to head pediatric practice." Arch Pediatr Adolesc Med. 2007;161(7)690-696 This profession was support in division by a compromise from the Centers for Education and Research on Therapeutics, Agency for Healthcare Research and Quality. Please see the article for more information, furthermore as other authors, correspondent contributions and affiliation, trade and industry disclosure, scholarship and patronage, etc.



Also read about depression !



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