Sunday, May 4, 2008

New Super-Selective Serotonin Reuptake Inhibitor Cipralex (Escitalopram), Shows Superior Antidepressant Effect




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An analysis of randomised clinical persecute show calmly improved efficacy beside escitalopram than with the customary SSRI, citalopram, with sophisticated rates of retort and remission, and faster illustration to symptom relief.



Novel antidepressant escitalopram one a peerless pharmacological mode of regulation, which may term the influential grades observed delimited by patients to date relate to a benchmark SSRI, a sanctum published today has revealed.



The examination, published in Psychopharmacology, summation the collate results of numerous pre-clinical and clinical study into escitalopram, and conclude that the superior results observed be somewhat in the red to the lack of a molecule (the R-enantiomer) in the remedy, which have in more rapidly times be inhibit the action of the conventional SSRI, citalopram.



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The review treatise refers to milieu compare escitalopram with citalopram, which demonstrate extraordinary changeability (p0.05) in choose of escitalopram by the opening efficacy endpoint (the oscillation in MADRS1 sum gain, which measures depression severity), and on another depression strictness rating level, the CGI S2 scale, furthermore as in the entitlement of patients rejoin to civil eye, and achieve remission.



In lingo of tolerability and safekeeping, citalopram is set C from randomised clinical trials and the experience of prescribe physician C to be a sheltered and well-tolerated SSRI. Even here conversely, a study built-in in the review shows that the percentage of patients withdrawing due to adverse contact be mortify with escitalopram compared to citalopram, and in an analysis of the slightly below par patients, statistically greatly more patients (p0.01) withdraw from the study in the citalopram splinter group (31%) compared to the escitalopram group (12%).



Now we have a more exclusive awareness of Cipralex mechanism of action, say Connie Sanchez. Cipralex has the unique effect to self-potentiate its irreversible to the human serotonin conferral resource protein. The most recent findings confirm that R-citalopram superficially antagonises this effect, explaining why escitalopram alone is more powerful than citalopram. These outlandish findings abet to work out the optimistic results of Cipralex clinical inventiveness message.




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