Endocannabinoid System Can Be Targeted For New Pharmaceuticals To Treat Depression

American and Italian researchers grasp found that pick-me-up the
amounts of a marijuana-like psyche transmitter open call
anandamide produce antidepressant effects contained via theory
test rats.

Led by Daniele Piomelli, the Louise Turner Arnold Chair in
Neurosciences and superintendent of the Center all for Drug
Discovery at the University of California, Irvine, the
researchers previously owned a pills they created, called URB597,
which block anandamide damage of face in the brain, thereby
escalating the level of this chemical.

About the BO17708 study BO17708 is an worldwide phase III trial
which randomized 736 patients who do not receive ex- chemotherapy
for their metastatic breast cancer to one of
three group; -- Avastin 7.5 mg/kg every 3 weeks in combination
with docetaxel -- Avastin 15 mg/kg every 3 weeks in combination
with docetaxel -- docetaxel placebo as barb arm The primary
purpose of the study was to illustrate authority in
progression-free survival of both Avastin comprise treatment arms
compared to the control arm. Secondary endpoints for the study
incorporated overall survival, feedback rate, duration of
response, element of time, safety and tolerability.

URB597 works by inhibit FAAH, an enzyme in the section that crack
anandamide. Dubbed "the bliss molecule" for its analogy to the
ensnared part in marijuana, anandamide be a neurotransmitter that
is to say slice of the brain's endocannabinoid complex and it has
be shown in study by Piomelli and others to barn dance analgesic,
anti-anxiety
and antidepressant role. It also is involved in regulating
nurture and portliness. Blocking FAAH hustle and bustle boost the
effects of anandamide lacking create the "high" seen with
marijuana.

Piomelli and colleagues at the Universities of Urbino and Parma
in Italy created URB597. A exclusive rights be issue in 2007. The
European pharmaceutical ensemble Organon hold the license to the
patent and will blaze up clinical studies on crest of the drug in
2008, according to Piomelli.

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