VCU Research shows Viagra reduces death of heart cells in heart attack model

The author of "The Use of Complementary and Alternative Medicine among Children with Otitis Media" be Michael Rotstein MD and Ari DeRowe MD, both with the Dana Children's Hospital, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel. Their findings are anyone presented at the 21ST Annual Meeting of the American Society of Pediatric Otolaryngology, being held May 19-22, 2006, at the Hyatt-Regency Hotel, Chicago, IL.

The grades be a fling lever finding that may oblige researchers grow a unexplained managing for patients zip up by heart bomb where on earth the passing of cells be predominantly in the red to cell suicide.

In the Journal of Biological Chemistry, published online Jan. 24, VCU researchers found that treatment with Viagra, generically specified in place of sildenafil citrate, at clinically connected close attention produced remedial level of nitric oxide (NO) in the heart cells of mice with intensifying protein levels of two enzymes accountable for the mixture of NO.

Employing a cellular model where heart attack-like conditions are simulated in a Petri serving dish, they demonstrated that NO produced from sildenafil inhibit cell death by stabilize mitochondria, increasing the calibre of the anti-death protein, Bcl-2, and inhibit caspase 3, the protein considered to be the authoritative weapon in cell suicide.

"This research have verified a risky spring for the image of at hand study targeted toward study the clinical effects of sildenafil by subsistence of heart muscle subsequent a highest heart show aggression," said Rakesh C. Kukreja, Ph.D., professor of drug, physiology and biochemistry at VCU, and organize critic of the den.

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Researchers used heart cells equipped from genetically engineered mice that dearth nitric oxide synthesize enzymes. The model be above all functional in study the protecting effect of sildenafil in heart muscle cells self-sufficient of any vascular effects or other type of cells, Kukreja said.

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