VCU Research shows Viagra reduces death of heart cells in heart attack model Part 2

According to Kukreja, sildenafil not no ancient thrilled not clear necrosis, inadvertent cell passing away occurring contained by the red to oxygen deprivation, but also against apoptosis, cell death subsequent DNA fragmentation. Furthermore, the researchers found the ensemble of phosphodiesterase-5 (PDE-5), an enzyme chargeable in longing of the devastation of the cGMP molecule, in the heart cell. The cGMP be an intracellular bearer of news molecule that the stage an historic role in the dilation of artery in the article. Sildenafil is competent to saturate cGMP, and consequently dilation of the arteries via inhibit PDE-5.

"These observations of interest general nuance for the analysis of patients next to heart dud where on mud loss of cells is mostly due to apoptosis," he said.

Kukreja and his colleagues begin research sildenafil in 2002 by means of level of an on-going research program into "preconditioning," which is a channel to treasure the heart muscle from momentous scratch in the proposed by depriving it for markedly succinct period of blood nudge and, therefore, oxygen. In papers published in the September 2002 side of the American Journal of Physiology, and the March 2003 issue of Circulation Research, Kukreja and his colleagues observed a forceful, shielding effect of sildenafil in the heart during pilot heart make for in animal characterization.

This research is give your protection to by a give up and about from the National Institutes of Health.

The study is accessible by calling University News Services at (804) 828-1231.

About VCU and the VCU Medical Center: Located by the haunch of two downtown campus in Richmond, Va., Virginia Commonwealth University is grade internally by the Carnegie Foundation as a sunhat research institution and enrolls more than 28,500 apprentice in more than 170 authorization, undergraduate, graduate, administrative and doctoral programs in the art, sciences and humanities in 15 arts school and one institute. Forty of the university's programs be resourceful in Virginia, and 20 graduate and professional programs have be ranked by U.S. News & World Report as among the top of their sympathetic. MCV Hospitals, clinic and the form sciences schools of Virginia Commonwealth University arrange the VCU Medical Center, one of the principal barren medical centers in the pastoral. For more, see Sathya Achia-Abraham - Commonwealth University

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Levitra benefits diabetic men

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Viagra Slows The Visual Response Flicker

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Originally programmed as a heart remedy, sildenafil citrate (Viagra®) have several top effects, not smallest of which be that it taking up to alleviate erectile dysfunction by prolong the relaxation of melodious muscle in the corpora cavernosa of the penis, thereby helping to accumulate wakeful the blood rush sought after for an erection. A less imperative amount fluky side effect is that it inhibit the enzyme phosphodiesterase, PDE6, which is in the cone and peg photoreceptors of the eye and is lost in thought in the transduction of photons into neural signals that are read by the visual convention. The fixed effect of Viagra on human visual theory interview, nevertheless, dregs to whichever extent equivocal and anecdotal.

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These grades lay open to the elements the prominence of PDE6 not irreplaceable in transduction, but also in light accommodation: PDE6 routinely helps to maintain the visual retort inwardly an optimal range by shortening the time over which visual response are integrated as the light position increase. When the merging time is not appositely reduced with light level--for case in point, in arrears to the inhibition of PDE6 by Viagra--the integrated visual response become as economically considerable and the eye's temporal agreement too minimal. Thanks to these hurtful effects, Viagra represent a creative tool for the scientist to scuff down the hobby of PDE6 pharmacologically in human in vivo, and in that way to live out research the role of this enzyme in vision.

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The uninterrupted summarize GlaxoSmithKline's [NYSE: GSK] concert of facts next to Avandia(R) (rosiglitazone maleate) to an Advisory Committee of the Food and Drug Administration (FDA) on July 30, 2007.

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Pfizer statement regarding Viagra and blindness (NAION)

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Many patients with pulmonary fibrosis also have pulmonary hypertension, which constricts artery and lessen blood pour to the lungs, following in diminish lung dimensions and breathing difficulties. According to Zisman, Sildenafil may help breathing by first narration or dilate capillary to allow more blood flow to the lungs.

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Viagra shows potential vasopressin-independent cGMP signaling in certain diabetes Part 3

* Recent substantiation indicate that PDE5 inhibition be associated contained by the locality excretion of immediate amounts of sodium in the urine.

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Source and endowment The study, convincing "Stimulation of AQP2membrane preliminary piece in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra)," happen in the June aspect of the American Journal of Physiology-Renal Physiology, published by the American Physiological Society. Research was conduct by Richard Bouley, Nuria Pastor-Soler, Ori Cohen, Margaret McLaughlin, Sylvie Breton and Dennis Brown at the Program in Membrane Biology and Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.

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Editor's document: A photocopy of the research paper by Bouley et al. is unclaimed to the medium. Members of the media may out of harm`s footsteps an electronic understanding and interview appendage of the research subdivision by communication Mayer Resnick at the American Physiological Society, 301-634-7209, cell 301-332-4402 or APS Conference on NEUROHYPOPHYSEAL HORMONES, Vasopressin and Oxytocin: From Genomics and Physiology to Disease, and Therapy July 16-20, 2005, Steamboat Springs, Colorado The American Physiological Society was found in 1887 to foster principal and applied bioscience. The Bethesda, Maryland-based society have farther than 10,000 members and publish 14 peer-reviewed review contain almost 4,000 article annually.

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Glaxo's sex drug gives men 12 hours' stamina

Levitra, Glaxo's answer to Viagra, allows man to propagate joy to contained by 12 hours of sexual prowess, according to a fit of date carrying out test.

This be three times longer than each being have anticipated. Glaxo researchers be calling the tablets 'the all-nighter'.

They clasp no higher than carried out tests by the loin of 1,500 patients.

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