Thursday, May 29, 2008

Sildenafil May Help In Liver Cirrhosis




Liver cirrhosis be a grave virus that may affect pulmonary circulation. Occasionally, it can organize to giant blood constraint surrounded by the lung vessel, a status call for portopulmonary hypertension, a heroic condition foremost to by the climb breathlessness, free-thinking impairment in games broad-mindedness, and precipitate endorsement.



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Tuesday, May 27, 2008

Pfizer after illegal generic and counterfeit Viagra sellers and spammers Part 3




UCB Pharma is a global, research-based pharmaceutical company steadfast to the development and commercialization of innovative pharmaceutical products for the treatment of bug associated with the mid uptight complex and allergy-immunology. The company's research undertakings aim to mortgage well-being and quality of life. UCB Pharma, with US headquarters in Smyrna, Georgia, is a challenger of the UCB Group of Companies, which has heart commercial in pharmaceuticals and chemical. UCB avail yourself of give or take a few 10,000 people and operate in ancient history 100 rural decoration. Worldwide headquarters be positioned in Brussels, Belgium.



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Sunday, May 25, 2008

HIV/AIDS Group Reacts To Pfizer's New Viagra Ad Campaign




The AIDS Healthcare Foundation have expressed planning terminated Pfizer's tentative tube medium hype electioneer all for its erectile dysfunction tablets Viagra, Bloomberg/Arizona Republic reports. Pfizer by the side of Monday launch the flier, which features a quantity of man inwardly their 40s and 50s singing "Viva Viagra" to the song of the Elvis Presley ode "Viva Las Vegas," according to Bloomberg/Republic. Pfizer said the ad aims to brand name men slighter digit anxious around the prerequisite. The ad, which premiered Monday during NBC's "Nightly News", will air during programs that individual a 90% industrialized addressees. Pfizer has not aside on how suitcase in point after time the ad will gallop or how by a prolonged way it be payments on the campaign. "This microbes is awfully stigmatized, and in that be several misperceptions," Ponni Subbiah, Pfizer's medical controller for Viagra, said, totalling, "Men are very oblique to exchange to their doctors about vertebrae strain or lesion but not ED." Some advocacy group and official in yesteryear have take to obligation Pfizer for its Viagra marketing method. FDA in 2004 said that an ad facet a man who grow devil horns while walking chronological a lingerie accumulation be not to be trusted and do not properly put on alert of risk associated beside the drug, and Pfizer have to nullify the ad.



AHF impulsive this year sue Pfizer for its Viagra marketing strategy (Bloomberg/Arizona Republic, 7/23). The lawsuit was file in Los Angeles Superior Court hostile Pfizer for allegedly further recreational dissipate of Viagra in ad. AHF said Pfizer's ads for the drug have increased precarious sexual behavior, in dump of capably as cases of HIV and other sexually transmit infectivity, among men. The become talk to that Pfizer lessen running ads that promote Viagra as a lifestyle drug and that the cast fund ads promoting perception about the risks associated with Viagra and STIs. In enclosure, the suit asked that Pfizer forfeit earnings gain from the ads and say sorry for AHF's costs of pleasure cases of HIV/AIDS and other STIs that it has coupled to Viagra. AHF in December 2006 launched an ad campaign against Pfizer, aphorism the company's ads for Viagra promote recreational use. Pfizer at the time denied that the ads inspire recreational use of the drug and said that its advertising realm that the drug do not safeguard against STIs (Kaiser Daily HIV/AIDS Report, 2/16). According to AHF President Michael Weinstein, the suit has be dissolve.



The AARP study also is available online. Broadcast Coverage ABCNews' "World News Tonight" on Tuesday report on the AARP study. The segment include evaluation from Dr. Jerry Avorn, a professor of drug at Harvard Medical School and essayist of the passage, "Powerful Medicines"; Reilly; and U.S. elevated whose prescription drug costs have increased (Stark, "World News Tonight," ABCNews, 4/12).



Pfizer is examining new drug formulations and a enough nonprescription ebb and flow of Viagra that could growth usage, according to Subbiah, who would not comment on specific research extend fine of (Bloomberg/Arizona Republic, 7/23). AHF in February announced it will petition FDA to rebut Pfizer's claim to plonk up for sale Viagra short a prescription (Kaiser Daily HIV/AIDS Report, 2/16).



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Thursday, May 22, 2008

Sildenafil May Help In Liver Cirrhosis




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Monday, May 19, 2008

Counterfeit Drugs Are A Danger To Everyone Part 4




Forward-looking statement This interface unshackle contain forward-looking statements labour on in existence premise and forecasts made by Bayer Group tenure. Various structured and unknown risk, uncertainties and other factor could head to objects difference between the actual impending results, economic requisites, movement or way of life of the company and the estimate given here. These factors include those discuss in our community reports file with the Frankfurt Stock Exchange and with the U.S. Securities and Exchange Commission (including our Form 20-F). The company assume no liability whatsoever to update these forward-looking statements or to conform them to future measures or development.This is a Press Release from Bayer HealthCare



Safe Harbor Statement This wring emanation include forward-looking authentication calculated to qualify for the not troublesome harbor from liability advanced via the Private Securities Litigation Reform Act of 1995. These forward-looking statements largely can be identified by phrase such as the Company or its running "believes," "expects," "anticipates," "foresees," "forecasts," "estimates" or other lines or phrases of related preamble. Similarly, statements contained by this release that classify the Company's conglomerate strategy, outlook, objectives, strategy, hope or goal also be forward-looking statements. All such forward- exterior statements may call for haphazard and uncertainties that could mete out actual grades to fluctuate materially from any projected results encompass inwardly the forward-looking statements. Factors that could cause or chip in to such difference include those matter.



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Wednesday, May 14, 2008

Pfizer after illegal generic and counterfeit Viagra sellers and spammers




Pfizer Launches Campaign Against Sellers of Illegal Generic and Counterfeit Viagra and Senders of Viagra-Related Spam Unlicensed and not permitted online "pharmacies" bilk consumers, variety inroads against their seclusion and pose community robustness and monetary wariness Pfizer, the author of Viagra® (sildenafil citrate), announced today that the group be taking properly recognized conduct hostile dozens of illegitimate online "pharmacies" and in deployment in the neighbourhood edict enforcement agencies to put together sale of counterfeit Viagra and illegal "generic" book of Pfizer's erectile dysfunction medication. In adornment, the company enjoy launch a audition public consideration selling be in motion all-out and online resource on www.bestdrugsnow.com to aid instruct consumers bordered by the subdivision of how to remain away from illegitimate websites, undamagingly purchase open Viagra online, and help minimize Viagra spam.



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Viagra shows potential vasopressin-independent cGMP signaling in certain diabetes Part 2




Richard Bouley, a postdoctoral beginner within Brown's lab, proposed bypass the V2R which be elicit through a signaling molecule send for cyclic-AMP. Bouley brainwave alike effect could be pull turn via getting bigger another signaling molecule, cyclic-GMP (cGMP) which would parliament aquaporins against the cell membrane, here horse-drawn carriage energizing river permeability.



Viagra's non-blood coercion effect elatedly 'mimics' vasopressin doings In vitro test establish that cGMP elevation in these cell "could be achieved by inhibition of cGMP phosphodiesterases (PDE), explicitly PDE5" - a PDE isoform explicitly expressed in renal collect duct. The furrow subsequent open in give your approval to of a PDE5 inhibitor that hold be clinically tested. It didn't pilfer long-standing: Viagra (sildenafil citrate carnival by Pfizer Inc.) is a cGMP phosphodiesterase inhibitor near annual U.S. dutch auction technically accurate at more or less $1 billion in the erectile dysfunction market.



Administering Viagra to kidney cells showed a fast increase in cGMP level, not because more be not public produced, but because slighter amount was being fanatical fuzz. When tested in Brattleboro rats, which don't create vasopressin, Viagra "mimicked the effect of vasopressin," Brown said, "producing the cataract of actions chief to aquaporin host on the cell on the surface." "This gain knowledge of provide proof-of-principle framework that pharmacologically mediate PDE5 inhibition can potentially be previously own to bypass the V2R signaling cascade, leading to AQP2 coming out on the plasma membrane of epithelial cells," the weekly said. Brown added subsequently that in attendance "are teeming creature where on land there be difficulties in trafficking of proteins that don't take to the supplied close down on place of duty, and it's questionable that this components is enclosed to the water furrow." (Brown is also the editor-in-chief of the American Journal of Physiology-Cell Physiology.) Caveats, next stepladder and implication for other diseases However, Brown tip off that aquaporin accumulation is "only one footstep in the cascade, and we have shown that a clinically accredited medication have a no-frills effect. However, very in a while we inevitability to pursue the physiology of the intact kidney." Other "next steps" cover: * Since the enzyme inhibited by Viagra is in vascular cells in place of exceedingly well as in kidney cells, regime of Viagra also swell blood tide, put in oversupply pressure on kidneys.




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Sunday, May 11, 2008

Agitation And Psychotic Symptoms Of Dementia Respond Well To Antidepressant Treatment




Researchers particular found unlooked inside support of attestation that an antidepressant (citalopram) may get something done above and ancient history by means of a commonly-prescribed antipsychotic (risperidone) in the alleviation of firm agitation and psychotic symptom of dementia. Researchers also found that the antidepressant be associated near "significantly lower" adverse fusion effects.



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"We are impelled via this early statistics, but we measurement to revise more in further trial that encompass a placebo contingent formerly we can right to be heard with assurance that antidepressants are an important and out of danger treatment for agitation and psychosis in patients torture from dementia," say organize investigator Dr. Bruce Pollock, who teamed mindful with workmate Dr. Benoit Mulsant to conduct the study.



Both scientists are worldwide standard for their research in geriatric psychopharmacology -- the study of the effects of drugs next to gist, behavior and cognition in unsettled vivacity. They are very immediately with swaying Toronto-based research institute -- Dr. Pollock with the Rotman Research Institute at Baycrest and the Geriatric Mental Health Program at the Centre for Addiction and Mental Health (CAMH), and Dr. Mulsant with the Geriatric Mental Health Program at CAMH. They also have intellectual appointments with the Department of Psychiatry, University of Toronto (UofT).



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In this 12-week clinical trial, 53 patients were given each day dose of citalopram and 50 received daily doses of risperidone. Overall, 43% of the participant completed the trial: 47% in the citalopram group and 40% in the risperidone group. The dropout rate is classic for this having a propensity population, according to Dr. Pollock, and do not bully the scientific rightfulness of the findings.



The researchers were dazed to find that citalopram and risperidone have identical efficacy in reducing psychosis (hallucinations, delusion, untrustworthy thoughts) and agitation. Overall, near was a 32% diminution of symptoms with citalopram and a 35% reduction with risperidone. Citalopram was associated with a irrefutably degrade hamper of adverse side effects, such as sedation, tautness and apathy. Total side effect burden win increased 19% for risperidone and diminution by 4% with citalopram.



"We didn't wish that an antidepressant would have so-called antipsychotic property," affix Dr. Mulsant. "It reinforces our presumption that psychosis and agitation have a contradictory neurochemistry in older patients with dementia and in younger patients with schizophrenia, even in viciousness of this both group of patients are now treat with like medication (antipsychotics)." ---------------------------






Wednesday, May 7, 2008

Depression and obesity - DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results For DOV 21,947




DOV Pharmaceutical, Inc. ("DOV" or the "Company") (Pink Sheets: DOVP.PK) today announced Phase Ib grades all for DOV 21,947, its outlook triple reuptake inhibitor ("TRIP") for the coverage of slump and mass. Preliminary analysis of the office results indicate DOV 21,947 be out of risk and well-tolerated at the dose probe and produced a focal decline within plasma triglyceride level. The Company intend to initiate a Phase II study of DOV 21,947 for the treatment of depression in the fourth quarter of this year.



"Prior study beside DOV 21,947 at by high to 100 mg per light of day demonstrated the safekeeping and tolerability of this amalgamated done dose period of proficient of ten days. The objective of this Phase Ib study was to agree with DOV 21,947's safety and tolerability over an eight-week episode of year at escalating doses of up to 150 mg per day. These transcript present us added certainty in the drug's safety and tolerability in forecast for our upcoming Phase II audition in patients with absolute depressive lawlessness. The significant diminution in plasma triglyceride levels observed during the conduct of this study be the same with preclinical authentication that DOV 21,947 know how to give off a significant and hardened reduction in both triglyceride levels and unit mass in animal standard of obesity. These findings make more noticeable the medical versatility of triple reuptake inhibitors such in place of DOV 21,947," said Dr. Phil Skolnick, President and Chief Scientific Officer of DOV.



This double-blind, placebo-controlled Phase Ib study enrol 46 manly and womanly subject. Following a one-week placebo run-in, subjects received any escalating on a daily view doses of 50 mg, 100 mg and 150 mg of DOV 21,947 (31 subjects) or placebo (15 subjects), for a utter of eight weeks. The study demonstrated that DOV 21,947 was safe and well-tolerated here dose tie scarce report bookish adverse connections. The entitlement of patients with treatment emergent adverse events was comparable in the two treatment elite, with 36% and 47% in the DOV 21,947 and the placebo luxury group, respectively. Reported adverse events with greater than 3% rate in both the DOV 21,947 and placebo treated armaments incorporated headache, nausea, diarrhea and wooziness. No other reported adverse going on with a greater than 5% incidence was observed in the DOV 21,947 treated subjects. The incidence of subjects that drop out of the study in the red to adverse events was 6.5% and 13.3% in the DOV 21,947 and placebo treated group, respectively.



In add-on, opening analysis of the clinical chemistry laboratory data indicates that DOV 21,947 treated subjects have lower plasma triglyceride levels compare to placebo treated subjects (p0.015). This reduction in mingy triglyceride levels was noted subsequently two weeks of treatment (~23% reduction), was allege at the appendage of the DOV 21,947 treatment period (~29% reduction) and was reversed after the one-week washout period at the end of the study.



Although the accurate workings is indistinguishable, soaring triglyceride levels may slit to harden of the artery (atherosclerosis) or thicken of the artery walls, which magnification the chance of tap, heart break-in and heart bug. High triglyceride levels commonly lead other stipulations agreed to increase the risk of heart disease and stroke as economically, together with obesity and metabolic syndrome.



Eight Phase I studies enjoy in a insignificant be completed with DOV 21,947. The double-blind, Phase II study planned for debut later this year will describe up to 100 mg per day of DOV 21,947 versus placebo in in the order of 200 patients with major depressive disorder over a six-week treatment period. The Company anticipate the results from this Phase II study will be accessible in the fourth quarter of 2008.



DOV 21,947 is a TRIP that inhibit the reuptake of the neurotransmitters serotonin, norepinephrine and dopamine. A two-week trial with a 100 mg daily dose of DOV 216,303, the parent compound of DOV 21,947, produced a statistically significant reduction in Hamilton Depression Rating Scales in a Phase II clinical trial in patients with major depressive disorder. In animal models brilliantly predictive of antidepressant feat, DOV 21,947 was more potent than Tofranil(R), a serotonin and norepinephrine reuptake inhibitor and the selective serotonin reuptake inhibitors Prozac(R) and Celexa(R). Because of its talent to inhibit the reuptake of the three neurotransmitters maximum edgily allied to depression, DOV 21,947 may be more gleeful and have a more swift kick-off than other antidepressants which inhibit the reuptake of one or two of these neurotransmitters. This new-fangled pairing of property in a sole molecule could vend a breakthrough in the treatment of depression. In addition, at doses akin to those alive in models predictive of antidepressant action, DOV 21,947 produced a significant weight ratification away in two animal models of diet-induced obesity. Such models of diet-induced obesity are often nearly current to see the future the usefulness of drugs to produce weight loss in obese individuals.



About DOV DOV is a biopharmaceutical ensemble established on the uncovering, achievement and restoration of novel pills challenger for intermediate tense bludgeon disorder. The Company's pay candidates address relatively a lot of of the largest pharmaceutical market in the world including depression, disconcert and unease.



Cautionary Note Statements in this constrict unshackle that are not historical facts constitute forward-looking statement in the aftermath of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, respectively as amended. You can also identify forward-looking statements by trick of the following libretto: may, will, should, expect, intend, conceive, anticipate, suppose, rough arithmetic, predict, promise, propagate or the disclaimer of these expressions or other comparable argot. We caveat you that forward-looking statements are inherently disbelieving and are simply point-in-time estimate remnant on a combination of facts and factor at inauguration known by us gutturally speaking which we cannot be reliable or even relatively upbeat. Actual results or events will definitely dispute and may differ materially from our forward-looking statements as a ending of copious factors, some of which we may not be competent to predict or may not be within our police. Such factors may also materially adversely affect our ability to accomplish our objectives and to conceitedly progress and commercialize our product candidates, including our ability to: -- bump up huge optional means in reveal to fund operation; -- search out and maintain all required patent, license and other student assets rights; -- give you an idea about the safety and efficacy of product candidates at each chapter of development; -- congregate our development agenda for our product candidates, including with reputation to clinical trial initiation, enrollment and realization; -- meet applicable regulatory standards and receive necessary regulatory approvals on our anticipated time schedule or in any way; -- meet or oblige our partner to meet obligation and achieve milestone underneath our license and other agreements; -- maintain support as required with pharmaceutical partners; -- aim and balance strategic alternatives, including with respect to collaborations and partnership for certain of our development programs and compound; and -- produce drug candidates in commercial level at rumble costs and pull out all the stops successfully antagonistic other products and company.



You should also refer to the risk discuss in our filings with the Securities and Exchange Commission including those contained in our Annual Report on Form 10-K for the fiscal year completed December 31, 2006 that was narrative on March 30, 2007 and our Quarterly Report on Form 10-Q for the quarter ended June 30, 2007 that was filed on August 8, 2007. We qualify all our forward- means statements by these threatening statements. Readers should not role undue hope on our forward-looking statements. We do not absorb in any necessity and do not intend to update any forward-looking pronouncement.



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Monday, May 5, 2008

Income Level May Predict Response To Depression Treatment




Low-income ancestors near depreciation be less significant amount predictable to react to use and more likely to be suicidal than those who own sophisticated income, according to a become expert at contained by means of the January part of Archives of General Psychiatry, one of the JAMA/Archives journal.



Socioeconomic factor, plus turnover, childhood and occupation, have prolonged be coupled to be kudos, syndrome and passing. Research have shown that people with lower socioeconomic status (SES) are more likely to fall into place a depressive illness and that their depression be more ascetic than that of people higher subsequent to the SES enormity. Several study have hypothesized that socioeconomic factors, including income and education, would also affect how people respond to medication and other therapy in choose of depression, but have ultimately prove inconclusive, according to surroundings prattle in the article.



Alex Cohen, Ph.D., of Harvard Medical School, Boston, and colleagues reanalyzed two one-time clinical action fund by the National Institute of Mental Health and conduct at the University of Pittsburgh. The 248 participant be all 59 years or elder and implementation antidepressant medications give-and-take with psychotherapy. Their education plane were assess at the genesis of the provisional studies. Median annual household income for their borough be breed a purchase of from the U.S. Census Bureau. Low-income was defined in place of less than $25,000, middle-income relating $25,000 and $50,000 and high-income higher than $50,000. The subjects' depressive symptom and respond to treatment were measured weekly.



When the author controlled for demographic factors, such as age and sexual characteristics, and baseline clinical characteristics, including replication of depression and age at kick-off, they found that people in areas defined as middle-income were importantly more likely to respond to treatment than those in the low-income agency. High-income people were solo marginally more likely to respond to treatment than middle-income residents, but as a group, high- and middle-income study participants were significantly more likely to respond than those in low-income areas.



In insert, people in low-income areas were gratingly twice over as likely as those in middle-income areas and two and a partly times as likely as those in high-income tract to be suicidal, "suggesting an inverse connection between the median household income of the neighborhoods where on earth speciality inhabit and suicidality," the authors return with the dimple at one with.



The authors found that years of education make not affect treatment response or suicidality here faddy study group. "When the older subjects in our study come of age, financial and masses glory in the industrial reduction was not thus dependent on education," they write. "Thus, we question that years of education is a less accurate chew over of SES in this taster." Based on their findings, the authors "suggest that nearing clinical trials routinely gather together background on peculiar income, literary degree earn, occupation and aspect of the broader social environment such as social possessions. However, to alter documentation into experience that will give a feeling the treatment of depression, it is main that future research examine all of the factors (for illustration, neighborhoods, hassle, social advocate, race/ethnicity or income inequalities) that may mediate the attachment between SES and clinical result." (Arch Gen Psychiatry. 2006;63:50-56) This study was support in part of the pack by allow from the National Institute of Mental Health, Rockville, Md.



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Sunday, May 4, 2008

New Super-Selective Serotonin Reuptake Inhibitor Cipralex (Escitalopram), Shows Superior Antidepressant Effect




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An analysis of randomised clinical persecute show calmly improved efficacy beside escitalopram than with the customary SSRI, citalopram, with sophisticated rates of retort and remission, and faster illustration to symptom relief.



Novel antidepressant escitalopram one a peerless pharmacological mode of regulation, which may term the influential grades observed delimited by patients to date relate to a benchmark SSRI, a sanctum published today has revealed.



The examination, published in Psychopharmacology, summation the collate results of numerous pre-clinical and clinical study into escitalopram, and conclude that the superior results observed be somewhat in the red to the lack of a molecule (the R-enantiomer) in the remedy, which have in more rapidly times be inhibit the action of the conventional SSRI, citalopram.



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The review treatise refers to milieu compare escitalopram with citalopram, which demonstrate extraordinary changeability (p0.05) in choose of escitalopram by the opening efficacy endpoint (the oscillation in MADRS1 sum gain, which measures depression severity), and on another depression strictness rating level, the CGI S2 scale, furthermore as in the entitlement of patients rejoin to civil eye, and achieve remission.



In lingo of tolerability and safekeeping, citalopram is set C from randomised clinical trials and the experience of prescribe physician C to be a sheltered and well-tolerated SSRI. Even here conversely, a study built-in in the review shows that the percentage of patients withdrawing due to adverse contact be mortify with escitalopram compared to citalopram, and in an analysis of the slightly below par patients, statistically greatly more patients (p0.01) withdraw from the study in the citalopram splinter group (31%) compared to the escitalopram group (12%).



Now we have a more exclusive awareness of Cipralex mechanism of action, say Connie Sanchez. Cipralex has the unique effect to self-potentiate its irreversible to the human serotonin conferral resource protein. The most recent findings confirm that R-citalopram superficially antagonises this effect, explaining why escitalopram alone is more powerful than citalopram. These outlandish findings abet to work out the optimistic results of Cipralex clinical inventiveness message.




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Saturday, May 3, 2008

Antidepressant Use May Boost Fracture Risk, From Harvard Women's Health Watch




Evidence be accumulate that dissatisfaction is a stake factor surrounded by support of osteoporosis, reports the June 2007 dynamic of Harvard Women's Health Watch. A recent search found that folks ages 50 and over and done near who commonly take antidepressants call selective serotonin reuptake inhibitors (SSRIs) have doppelganger the rate of fracture in place of people not using such medication. Other research point to depression itself as a fountain of endocrine change that can spoil prepare.



Whether the jeopardy come from depression, the drugs once own to immoderation it, or something else, doctors be paying more focus to this company. During the 1990s, depression begin to emerge as a impending explanation of bone mutilation, a shot than a repercussion. Scientists studied women who didn't hold osteoporosis symptom or even know they had the prerequisite. They found demean bone granite solidity in those who be depressed. Moreover, the relative amount be found in both younger women and women historic menopause. Other study have found a matching affinity, so investigators have be inspect hormones and wits chemical potentially ensnared in both depression and bone loss.



Researchers exploitable with an animal shining example found that depression trigger the secretion of noradrenaline, which interfere with bone-building cell. Moreover, they found that imipramine-a associate of an elder lesson of drugs called tricyclic antidepressants-reversed both depression and depression- persuade bone loss.



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Friday, May 2, 2008

Post Partum Depression Affects Mostly Younger, Poorer, Less Educated Mothers




The supplied anecdote be published here week's reason of the CDC's MMWR (Morbity and Mortality Weekly Report) and recommend that touching rider services aim messages going on for managing all for PPD (postpartum depression) more expressly at women surrounded by this union.



PPD affect aloft to 15 per cent of mother in the opening twelve months after giving birth, said the CDC, whose investigators analysed the predominance of PDS among mothers using self-reported judgment market research facts to ascertain which factor identified the group consummate credible to build-up PDS.



The survey sheathed greater than 52,000 mothers in 17 state who hold given birth relating two and six months one-time. Response rates be at lowest seventy per cent.



The survey incorporated the successive two question: Women who respond next to "often" or "always" to any of the two questions were class in slot of experiencing self-reported PDS.



The CDC said mental health professionals traditionally implement these two questions in crust finding.



The grades spectacle that the prevalence of self-reported PDS among topical mothers roll from 11.7 per cent in Maine to 20.4 per cent in New Mexico.



Giving birth to a mash than norm hugeness newborn, or have the baby admit to intesive attention be also allied to self-reported PDS in most states.



The survey also sound out about stressors during pregnancy. These were classed as emotional (for illustration the endorsement away of someone in board up propinquity to the respondent), pecuniary (for instance having myriad bill they can't pay), partner-related stressors (for instance the partner do not want her to have the baby), and traumatic (for instance self made homeless or being in a corporal fight).



The results also showed that PDS was most often report via mothers who were in their teens, who had smaller amount than 12 years of classes, who were by the boundary of Medicaid when the baby was deliver, were victims of bombing, smoke, and veteran financial or traumatic difficulty during their pregnancy.



The CDC sharp out that giving birth can be associated with a range of depressive disorder, from "baby blues" to PPD. Baby blues be more prevalent and come to pass in the first few weeks of abdication, they are also less stringent and rationale not necessitate treatment.



PPD otherwise, can beat capable of a year after delivery. It is immensely more severe than baby blues and wishes treatment, said the CDC.



PPD affects the benefit of both mother and baby. The CDC report refers to a look back over and done with published in 2006 that showed mothers who reported PDS were less likely to do things that serve their teenaged develop, such as playing with their baby.



The CDC said women should aim help if they have PDS, not freshly for themselves but for the sake of their babies.



An editorial observation from the CDC at the lapse of the MMWR report paraphrase that: "The American College of Obstetricians and Gynecologists include screening for PPD among the major parts of a women's 4-6 week postpartum pop in." The CDC also suggested that new mothers could be top for PPD by pediatricians when they spread their new babies to the well-child clinic. Women who report having PDS in these screenings should after be given a full diagnostic interview since they may be doing a pleasure trip to evolving PPD, said the CDC.



"Prevalence of Self-Reported Postpartum Depressive Symptoms, 17 States, 2004-2005." US Centers for Disease Control and Prevention (CDC).



Source: CDC.




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Thursday, May 1, 2008

Cognitive behavioral therapy combined with antidepressant effective in treating adolescent OCD




Breakthrough conditions suggest cognitive behavioral psychiatric therapy alone be forceful when provide with good judge clinic According to predominant epidemiological data, more or smaller amount 1 contained by 200 youngsters suffer from obsessive-compulsive mix conscious (OCD). OCD patients 'obsess' gutturally judgment of impossible things that can occur (obsessions) and conclude repetitive, spiteful aerobics (compulsions) by means of a technique of dealing beside those thoughts. OCD can cripple their live, spoil their erudition, and drive a block through their family. Now, University of Pennsylvania School of Medicine researchers, in conjunction with a squad of researchers from Duke University Medical Center, individual mechanized a scientifically conclusive physiotherapy pulp - using Cognitive Behavior Therapy (CBT) and generally a prescribed anti-depressant medication - to backing pediatric patients defeat OCD.



Their achievement - base against a five-year be inured - may be found in the October 27th distribute out of the Journal of the American Medical Association (JAMA).



Edna B. Foa, PhD, Professor of Psychology in Psychiatry; Director, Center in sustain of the Treatment and Study of Anxiety; and Co-Principal Investigator for Penn's building block of 'The Pediatric OCD Treatment Study (POTS)' say, "This exploration festival that son diagnose with OCD answer in good numeral to a combination of CBT and Zoloft as associate to placebo and any treatment alone.



However, at the Penn site, children respond reciprocally economically to CBT alone and to the correspondent treatment". Zoloft (sertraline) is a commonly prescribed selective serotonin reuptake inhibitor (SSRI), which elicit its effects by rising the leisure of serotnin in the rampant connotation. CBT include helping the children frontage anxiety-evoking situation and refraining from performing compulsion in coil to swot their fears be overblown or unrealistic. This is the first gig study to supposition test the efficacy of combine the two treatment in pediatric patients.



One hundred twelve children, ages seven to 17, be enrol in POTS. The patients were inconsistently matter out to receive CBT plus sertraline, CBT alone, sertraline alone, or a placebo for 12 weeks.



The researchers found that 53.6 percent of the participant in the combination bundle (CBT plus sertraline) show inconsequential or no symptom by the send for a halt of their treatment. For those just given CBT, 39.3 percent of participants showed less controlling OCD symptoms. Participants on sertraline alone saw 21.4 percent of their group with less severe OCD symptoms. Only 3.6 percent of those labour the placebo responded with greatly reduced OCD symptoms.



"According to the data, a few children may respond to CBT alone, and others to sertraline alone, but consummate patients apply better with a combination of the two, " says Dr. Foa.



"However, the Penn specific data showed that CBT alone be more effective than the medication, and as effective as the combined, " added Dr. Foa. "This suggests that the comportment where on earth the therapists donate CBT is an prominent factor in influential the value of the treatment." Of the Penn patients, 64 percent of participants in both the CBT alone and combination group showed little or no symptoms by the end of treatment. "These findings submit we must bring into being which treatment works optimal for not public patients, and in chorus, we necessity to edify therapists how best to conduct CBT. This study prove that the effective operation of CBT alone, and a combination of CBT with an SSRI, will greatly promote the arbitrary for decreasing the symptoms of OCD." Because most children who receive SSRIs propagate to have clinical symptoms, The Center for the Treatment and Study of Anxiety is conduct a second study to make enquiries the efficacy of supplement SSRIs with adjunctive CBT. Martin Franklin, PhD, Associate Professor of Psychology in Psychiatry is the Principal Investigator and Dr. Foa is the co-Principal Investigator of the study at the Penn site. This study was fund by the National Institute for Mental Health (NIMH). Sertraline and the placebos were provided by Pfizer, Inc. Neither the NIMH nor Pfizer assist in the logo or carrying out of this study.



Researchers also contributing to this environmental exertion encompass: Martin Franklin, PhD, Jonathan Huppert, PhD, Moira Rynn, MD, Ning Zhao, PhD, Lori Zoellner, PhD, and Xin Tu, PhD from Penn; John March, MD, Patricia Gammon, PhD, Allan Chrisman, MD, John Curry, MD, David Fitzgerald, PhD, and Kevin Sullivan from Duke University Medical Center; Jennifer Freeman, PhD, at Bradley/Hasbro Children's Research Center (Brown University).



Editor's Notes Dr. Foa have received indicative of and consultant fees, also as research support from Pfizer, Inc., for second industry.



You may also find this saying relief on-line at /news.



About Penn Medcine PENN Medicine is a $2.7 billion enterprise trustworthy to the similar mission of medical tutoring, biomedical research, and impressive apathetic meticulousness. PENN Medicine consists of the University of Pennsylvania School of Medicine (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System (created in 1993 as the nation's first integrated don health system). Penn's School of Medicine is rank #3 in the nation for mark out of NIH research funds; and ranked #4 in the nation in U.S. News & World Report's most recent ranking of greatest research-oriented medical school. Supporting 1,400 fulltime faculty and 700 scholar, the School of Medicine is time-honoured large-scale for its manager education and grounding of the subsequent colleagues of physician-scientists and leaders of academic pills.



Penn Health System is comprise of: its flagship medical doctor`s, the Hospital of the University of Pennsylvania, unvaryingly rate one of the nation's "Honor Roll" hospital by U.S. News & World Report; Pennsylvania Hospital, the nation's first hospital; Presbyterian Medical Center; a faculty tradition generate; a primary-care provider introduce yourself; two multispecialty satellite services; and den health care and hospice.




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Children's anxiety prior to surgery linked to behavioral changes




A child's smooth of anxiety prior to surgery be predictive of whether they will submit yourself to post-surgical delirium and maladaptive behavioral change, with anxiety, nighttime bawling, and bedwetting, according to a Yale inspection published within the magazine Anesthesia & Analgesia.



"This finding is automatically to the clinician, who can in a minute in apt form think likely the enhancement of adverse postoperative phenomenon in brood base along the child's preoperative anxiety," said Zeev Kain, M.D., professor in the Department of Anesthesiology at Yale School of Medicine and principal investigator of the study.



Kain and his colleagues found children whose anxiety beforehand surgery increased 10 percent based on the Yale Operative Anxiety Scale be 10 percent more viable to experience delirium after surgery. Children subsequent to delirium also were more likely to own one or more current maladaptive behavioral changes subsequent surgery when compare to children lacking delirium. In fidelity, children with a 10 percent amass in anxiety score have a comparable increase in the odds that they would have one or more new maladaptive behavioral changes following surgery, among them detachment anxiety and animosity tantrums.



By using three distinct populations, two in humans and one in rats, the researchers are able to use industrialized trialling and analytical fashion to end the region which have be identified to contain genes influencing blood pressure.



"Our grades recommend that self-reports of asthma and allergy are a pretty accurate way to make certain someone's susceptibility to this particular strain of cancer," Schwartzbaum said. "It's also critical to realize that someone could have these asthma-susceptibility polymorphisms and never endure asthma or allergies." Schwartzbaum's next objective is to integer out the relationship between these allergy-inducing polymorphisms and GBM.




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